In Puzzle 6, most players play JOY immediately. They reason that the A is a better tile than the O, the Y scores more points, and that the A can be used to parallel row 9. However, there are actually quite a few other options: JOY, JAY, JOG, and JAG are all good options.
JAY is actually the best play since it virtually guarantees a high scoring play next turn. The A is actually not much of a help, while JAY sets up a likely FOG play next turn for 29 points.